Effect on spontaneous metastasis of mouse Lewis lung carcinoma by a trifluoroacetamide analogue of siastatin B.
نویسندگان
چکیده
As reported in our previous paperslf2), (3R,4R, 5#,6#)-6-(trifluoroacetamido)-3,4,5-trihydroxypiperidine-3-carboxylic acid (tentatively named SF 1 ) and (35,4S',5K,6^)-6-(trifluoroacetamido)-4, 5-dihydroxypiperidine-3-carboxylic acid (SF4) which were synthesized as trifluoroacetamide analogues of siastatin B3) (Fig. 1), were highly inhibitory against /?-glucuronidase (EC 3.2.1.31) from bovine liver (IC50 0.073 and 0.029/iM, respectively) and
منابع مشابه
Totally synthetic analogues of siastatin B. II. Optically active piperidine derivatives having trifluoroacetamide and hydroxyacetamide groups at C-2.
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 47 7 شماره
صفحات -
تاریخ انتشار 1994